Importance of Biochemistry

Cov19 treatment an updated list of drugs

Cov19 treatment update

Cov19 treatment an updated list of drugs and medications?

Cov19 treatment update:

Cov19 treatment update are listed here in this article. Professor William Petri, a physician and scientist at the University of Virginia, USA, treating patients and conducting research to find the best methods for diagnosing and treating infectious diseases including Covid-19 virus. I share in this article our effective and failed medicines in treating emerging coronavirus infection, SARS-Cove-2.
Beaware that this field of medicine is developing rapidly as our understanding of the emerging coronavirus improves, so what I write today may change in a matter of days or weeks.

Cov19 treatment update.What Effective and Failed Drugs Are in Treating Covid-19 - Effective Medicines and Failed Medicines in Treating Emerging Coronary Virus Infection
Cov19 treatment update

Here are the tried and tested drugs we know the best:

Hydroxychloroquine or chloroquine:

No evidence of its effectiveness.

Three randomized controlled trials of hydroxychloroquine failed to demonstrate or disprove a beneficial or harmful effect on the clinical course of Covid-19 virus, and based on the current lack of evidence these drugs commonly used to treat arthritis should be used only in the context of a controlled clinical trial.

Lubinavir / ritonavir:

inactive.

Lopinavir is an inhibitor of an enzyme called the human immunodeficiency virus (HIV), which is involved in the production of the components of the virus. The inhibitors of the human immunodeficiency virus (HIV) were revolutionary, which led to our current ability to treat HIV effectively.

Lubinavir may also inhibit enzymes that perform similar functions to the HIV protease in coronavirus (CK) for SARS and MERS. Ritonavir increases the level of lupinavir in the blood, so the lopinavir / ritonavir formula has been tested in a randomized, controlled clinical trial of Covid-19.

Unfortunately, we did not notice an effect on virus levels in the throat or on how long the body got rid of the virus and the clinical course of patients and the chances of their survival did not change, so lopinavir / ritonavir is not effective in treating Covid-19.

Steroids:

Yes to give it to almost all Covid-19 patients.

When the synthetic steroid hormone dexamethasone was given to Covid-19 patients, death rates decreased by 17% over a period of 28 days, and hospitalizations were expedited.

This was done in a randomized controlled clinical study that included more than 6000 patients, and was not repeated in another study, and this study was not subject to peer review, so there is certainly no sufficient evidence to recommend the use of steroids.

Tossilizumab:

We do not have a final judgment yet.

Tocelizumab is an antibody that prevents a protein called interleukin-6 from binding to receptors and causing inflammation. Interleukin-6 levels increase in many Covid-19 patients and the immune system generally appears to be very active in patients with severe severe cases, leading many doctors to suspect that receptor blocking Interleukin-6 may protect patients from serious conditions.

The US Food and Drug Administration has currently approved Tocelizumab to treat rheumatoid (rheumatoid) arthritis and many other collagen vascular diseases and to treat “cytokine storm”, an excessive adverse reaction to the immune system that may be caused by certain types of cancer treatments and Covid-19.

A retrospective observation survey found that Covid-19 patients treated with Tosilizumab had a lower likelihood of requiring respiratory ventilation and had lower mortality rates, but we lacked a randomized controlled clinical trial, so we cannot verify whether this apparent improvement was caused by Tocelizumab or by the inaccurate nature Retrospective studies?

Homologous plasma for recovery:

We do not have a final judgment yet.

Homozygous plasma is the blood-derived fluid after removing white and red blood cells. This plasma contains antibodies from the previous infection that the plasma donor had previously had.

This plasma has been used for more than a century for the prevention of infectious diseases including pneumonia, tetanus, diphtheria (diphtheria), mumps and watery chickenpox for more than a century, and is believed to benefit patients because antibodies from recovered plasma are linked to or break down with pathogens or toxins in patients. Plasma is currently used in thousands of Covid-19 patients.

However, the only randomized clinical trial was small, involving only 103 patients who received plasma 14 days after their illness, no difference was observed in the time of clinical improvement or deaths between those who received treatment and those who did not receive it, but encouraging news indicated a significant decrease in detected virus levels By analyzing the polymerase chain reaction.

So it is too early to judge whether the symmetrical plasma will benefit the sick recover or not? We need disciplined clinical studies.

Cov19 treatment update.A recovery plasma nurse collects a recovered patient from Covid-19 to assist in the healing process of other Covid-19 patients in Indonesia.
Cov19 treatment update

A recovery plasma nurse collects a recovered patient from Covid-19 to assist in the healing process of other Covid-19 patients in Indonesia.

Remisdiver:

Yeah; Reduces hospital stay.

REMDESIVER is a drug that inhibits the coronavirus (Corona) enzyme that makes copies of the genetic tape of RNA, the viral RNA genome. It causes the early discontinuation or termination of the copies and ultimately prevents the virus from multiplying.

Remediffer therapy – especially in patients who needed supplemental oxygen before being placed on a ventilator – reduced mortality and shortened the average recovery time from 15 to 11 days.

Keep taking ACE inhibitor and angiotensin II receptor blockers.

Medicines called angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers are often used to treat high blood pressure and heart failure. Doctors have been concerned about these medications, as they may increase the levels of angiotensin-converting enzyme 2 proteins, receptors for severe acute respiratory syndrome on the surface of body cells. As doctors assume, this will allow more virus entry points to infect cells, thereby enhancing the severity of new coronavirus infections.

However, there is no evidence for this to actually happen. The American Heart Association, the American Heart Failure Association and the American University of Cardiology jointly recommend that patients continue to take these medications during the pandemic because they are useful in treating high blood pressure and heart failure.

We have made impressive progress in treating Covid-19 and two medications that have been helpful in helping patients, steroids and remediffer, have already been discovered.

Those who benefit from these treatments owe their thanks to the patients who have volunteered to participate in the controlled clinical trials, the doctors, and the pharmaceutical companies that lead them.

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