What is Dexamethasone used for?
Dexamethasone dosage :
Dexamethasone dosage is listed here first of all we have to know about its history.8 million positive cases of Covid-19 disease have been recorded in six months since the start of the pandemic from Wuhan, China.
Today, scientists announced the first important step in treating this disease, as a Oxford University research team discovered the effectiveness of the cheap and available dexamethasone drug on the market to treat Severe cases of Covid-19 disease.
Dexamethasone history :
Dexamethasone has been available since the early 1960s. It is an anti-inflammatory steroid often prescribed in small doses and is used to treat severe and allergic asthma attacks and in cases of joint pain and swelling, as well as to treat autoimmune diseases such as systemic lupus erythematosus, and is more commonly used in cases of rheumatoid arthritis.
The benefit of this drug when treating severe cases of Covid-19 lies in its anti-inflammatory properties and its effect on the immune system.
The way it works:
Most people with Covid-19 do not have symptoms of the disease, or have moderate symptoms, such as dry cough, loss of taste, smell, and mild fever. Symptoms are very severe in a small percentage of patients who need oxygen therapy or respiratory equipment to supply the lungs with the oxygen needed by the body, and dexamethasone has proven effective in treating this group of patients.
In severe cases, the immune system overreacts to the virus, attacking the cells carrying it, and the immune cells secrete chemicals called cytokines that cause acute inflammation. This condition is known as a “cytokine storm.”
Dexamethasone suppresses the immune system response and reduces the severity of the cytokine storm, protecting the heart and lungs from acute inflammation responsible for acute respiratory problems in severe disease.
Dexamethasone has been tested in the largest drug trial to treat Covid-19 so far, codenamed randomized evaluation of covid-19, or for hospitalization, in which researchers studied the effect of the drug in 2,000 patients and compared the results with 4,000 other patients who were not receiving treatment.
The results of the experiment, which has not yet been published in a peer-reviewed journal, showed that the greatest benefit of the drug appeared to patients placed on ventilators, as the drug reduced their risk of death by 30 percent. Mortality decreased by 20 percent in patients who were only receiving oxygen respiratory therapy.
This is roughly equivalent to saving the lives of one patient out of every eight patients placed on the respiratory system, and one in every 20 to 25 patients receive respiratory oxygen therapy.
Dexamethasone – like all other medicines – has side effects that include anxiety, sleep disorders, weight gain and fluid retention, but these symptoms are simple for Covid-19 patients in intensive care and can be controlled, that is, the benefits of dexamethasone in the treatment of Covid-19 far outweigh the harm.
But this drug is ineffective in patients with mild symptoms and do not need respiratory support, and patients are not recommended to use the drug at home.
The first real treatment:
Results of research on dexamethasone were combined in a randomized clinical trial in which the outcomes of patients who received treatment were compared with those of those who did not receive it.
Previous medications that some people have considered potential treatments for the emerging coronavirus have not been thoroughly studied in this pattern before their efficacy has been announced, such as the malaria hydroxy chloroquine promoted by French researcher Didier Raul and President of the United States of America Donald Trump, although statistics say this drug has caused an increase in Covid’s mortality rate is -19 and is not recommended for use.
Even Oxford researchers who discovered the efficacy of dexamethasone had stopped their studies on hydroxychloroquine due to its ineffectiveness, and the US Food and Drug Administration withdrew its use in treating Covid-19 disease.
Dexamethasone is a cheap drug that costs about $ 6 per day, and is treated with patients for 6 to 10 days. That is, we can save patients ’lives at a cost of no more than $ 44 per patient. Doctors estimated that using this drug earlier in the UK would have saved the lives of about 5,000 patients with Covid-19.
This drug is universally available in large quantities, and this means that poor patients in developing countries that lack comprehensive health care systems can access the drug easily, unlike new drugs that are often expensive and not available.
This important study suggests the possibility of using a drug that has been available on the market for sixty years in the treatment of Covid-19, thus announcing the first successful step in our battle against this disease in the hope of reaching new discoveries.
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