Basic chemistry

How does click chemistry work?

Click chemistry

 

How does click chemistry work?

Click chemistry :

Click chemistry aims to find simple, fast and flexible methods for clipping molecules together through robust links. Polish researchers have succeeded in applying this same method on a larger scale, to fix gold nanoparticles to a solid carbon substrate.

The chemistry click is a relatively new method of chemical synthesis . It draws on the “buttons pressure ” chemical to bind small molecular modules and build customized structures quickly and efficiently.

This method was previously used mainly for the synthesis of complex organic compounds .

 Researchers from the Institute of Physical Chemistry of the Polish Academy of Sciences (SAP IPC) Warsaw managed to apply the principle of click chemistry to gold nanoparticles they so fixed on a substrate of glassy carbon .

The idea of ​​click chemistry was born at the end of the last century. It is inspired by nature and especially the structure of proteins .

They consist of chains of amino acids all formed from the same type of bonds between an atom of carbon and an atom of nitrogen . The establishment of these so-called peptide bonds is facilitated by the action of enzymes .

 The click chemistry mimics the processes for the synthesis of organic compounds, like children build a structure using small block building . The benefits are many.

The reactions generally take place at room temperature and in a solventunique that often comes down to water. The reaction yield is particularly high since it is around 80 to 90%.

The IPC PAS team wanted to apply these principles to bulk bricks larger than molecules and sought to fix gold nanoparticles on a solid substrate .

Conventionally, the nanoparticles are simply deposited on the substrate and then attached thereto through weak physical links, electrostatic for example.

Thanks to click chemistry, Polish researchers have managed to fix the nanoparticles to their substrate by durable covalent bonds .

Stable carbon-nitrogen bonds

To achieve this result, the IPC PAS team used well-known chemical snaps. Groups formed of three nitrogen atoms, azides, are indeed likely, in the presence of a catalyst , to bind with groups of carbon atoms, acyls, located at the ends of various molecules to form particularly stable carbon-nitrogen bonds.

Here, the azides were added to the vitreous carbon substrate and the acyls to the gold nanoparticles.

The catalysis is based in turn on an electrochemical process. The whole process could be optimized so that the nanoparticles suspended around the electrode remain stable and the concentration of ions in the electrolyte remains the best.

 The use of electrochemistry rather than a more conventional chemical catalyst has also reduced the reaction time.

The work of the IPC PAS team could already make it possible to develop conservative detectors such as sulphites, effective and simple.

Polish researchers claim that their method is equally applicable to other substrates. What to consider the development of different types of chemical sensors .

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