A direct link between MITF and innate immunity ?
White hair a link with immunity :
White hair a link with immunity is listed here briefly in this article.A study conducted on mice explains why it is possible to have more white hair after an infection or chronic stress. The loss of hair pigmentation is associated with the activation of the innate immune system.
Sometimes, some people have moreafter a serious illness or chronic . A new study from the University of Alabama (United States) published in provides an explanation.
Researchers have discovered a link:
Researchers have discovered a link betweenthat contribute to the of hair (or hair) and those that inform the body of an infection.
When aor attacks the body, the innate kicks in.Cells respond by secreting , , which activate the defenses .
A transcription factor(MITF):
Here, the researchers found an unexpected link between gray hair, afactor (MITF) and innate .
In the 1980s, studies in mice had already shown that exposure to avirus (MuLV) promoted premature hair whitening.
Did you know ?
The color of the hair is due to the presence of a pigment produced by particular cells, the melanocytes. During aging, when the hair falls out and new hair grows, the melanocyte stem cells serve as reservoirs to produce new melanocytes. The loss of these stem cells leads to the formation of hair and white hairs.
The factor MITF :
The factor MITF plays a role in controlling different functions of the. In the mouse, if the mitf gene is not expressed, there is an almost total absence of melanoblasts in the , which gives, at birth, all white mice.
But MITF also has a link with the cell’s response to:
it reduces the expression of genes for the innate immune response in cells of the melanocyte line.
A link between hair color and the innate immune response:
The researchers worked with a mouse model predisposed to have white. In these animals, scientists have artificially activated the innate immune response, for example by mimicking a viral infection.
the mice had a significant loss of melanocytes and melanocyte, hence the presence of more gray hairs.
William Pavan, one of the authors of the study, said in a:
“This new discovery suggests that the genes that control thein the hair and skin are also working to control the innate. These results can improve our understanding of hair aging. Most importantly, discovering this connection will help us understand diseases like , with the involvement of the innate immune system. ”
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